Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Feb 1;314(2):C152-C165.
doi: 10.1152/ajpcell.00137.2017. Epub 2017 Oct 25.

The Diverse Cellular Responses of the Choroid Plexus During Infection of the Central Nervous System

Affiliations
Free article
Review

The Diverse Cellular Responses of the Choroid Plexus During Infection of the Central Nervous System

Alexa N Lauer et al. Am J Physiol Cell Physiol. .
Free article

Abstract

The choroid plexus (CP) is responsible for the production of a large amount of the cerebrospinal fluid (CSF). As a highly vascularized structure, the CP also presents a significant frontier between the blood and the central nervous system (CNS). To seal this border, the epithelium of the CP forms the blood-CSF barrier, one of the most important barriers separating the CNS from the blood. During the course of infectious disease, cells of the CP can experience interactions with intruding pathogens, especially when the CP is used as gateway for entry into the CNS. In return, the CP answers to these encounters with diverse measures. Here, we will review the distinct responses of the CP during infection of the CNS, which include engaging of signal transduction pathways, the regulation of gene expression in the host cells, inflammatory cell response, alterations of the barrier, and, under certain circumstances, cell death. Many of these actions may contribute to stage an immunological response against the pathogen and subsequently help in the clearance of the infection.

Keywords: blood-cerebrospinal fluid barrier; cellular response; central nervous system; choroid plexus; pathogens.

Similar articles

See all similar articles

Cited by 4 articles

MeSH terms

LinkOut - more resources

Feedback