Effects of methyl prednisolone, dimethyl sulphoxide and naloxone in experimental spinal cord injuries in rats

Neurol Res. 1988 Dec;10(4):232-5. doi: 10.1080/01616412.1988.11739847.

Abstract

The effects of methyl prednisolone (MPD), dimethyl sulphoxide (DMSO), and naloxone were examined in 38 albino rats after making an impact spinal cord injury on the midthoracic segments with a modified Allen's weight dropping trauma method. Somatosensorial evoked potentials (SEPs) were recorded before and 12 h and 14 d after the injury from epidurally inserted electrodes on the parietal cortex with sciatic nerve stimulations. Lower extremity motor functions of the animals were also examined. It may be concluded that in this study model, DMSO has a moderate effect which can be demonstrated clinically and through SEPs. Naloxone has no effect on the clinical outcome but causes reasonable improvement electrophysiologically.

MeSH terms

  • Action Potentials
  • Animals
  • Dimethyl Sulfoxide / therapeutic use*
  • Naloxone / therapeutic use*
  • Prednisolone / therapeutic use*
  • Rats
  • Spinal Cord Injuries / drug therapy*
  • Spinal Cord Injuries / physiopathology
  • Time Factors

Substances

  • Naloxone
  • Prednisolone
  • Dimethyl Sulfoxide