PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics

Circ Res. 2017 Oct 27;121(10):1136-1139. doi: 10.1161/CIRCRESAHA.117.311737.


The NIH/NHLBI launched an initiative, “Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics (PVDOMICS)” that aims to augment the current PH classification based on shared biological features. PVDOMICS will enroll 1,500 participants with PH and disease and healthy comparators. Enrollees will undergo deep clinical phenotyping and blood will be acquired for comprehensive “omic” analyses that will focus on discovery of molecular-based subtypes of PVD through application of high dimensional model-based clustering methods. In addition to an updated, molecular classification of PVD, the phenomic data generated will be a rich resource to the broad community of heart and lung disease investigators.

Keywords: National Heart, Lung, and Blood Institute (U.S.); National Institutes of Health (U.S.); diagnosis; hypertension, pulmonary; pulmonary artery.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • Hypertension, Pulmonary / diagnosis
  • Hypertension, Pulmonary / epidemiology
  • Hypertension, Pulmonary / genetics*
  • Lung Diseases / diagnosis
  • Lung Diseases / epidemiology
  • Lung Diseases / genetics
  • National Heart, Lung, and Blood Institute (U.S.) / trends*
  • Phenotype*
  • Pulmonary Circulation / genetics*
  • United States / epidemiology
  • Vascular Diseases / diagnosis
  • Vascular Diseases / epidemiology
  • Vascular Diseases / genetics