Abstract
The IC50 values for the in-vitro inhibition of the prostaglandin synthetase (bovine seminal vesicle mitochondrial fraction) mediated PGE2 production from arachidonic acid by parthenolide, michefuscalide and chrysanthenyl acetate were 11.0 +/- 0.44, 12.1 +/- 0.51 and 14.2 +/- 0.58 microM (mean +/- 95% confidence limits), respectively.
MeSH terms
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Bridged Bicyclo Compounds / isolation & purification
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Bridged Bicyclo Compounds / metabolism
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Cyclooxygenase Inhibitors*
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Monoterpenes*
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Plants, Medicinal / analysis*
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Prostaglandins / biosynthesis
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / metabolism
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Sesquiterpenes / pharmacology
Substances
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Bridged Bicyclo Compounds
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Cyclooxygenase Inhibitors
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Monoterpenes
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Prostaglandins
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Sesquiterpenes
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parthenolide
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chrysanthenyl acetate
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michefucscalide