Prostaglandin synthetase inhibitors in feverfew

J Pharm Pharmacol. 1988 Oct;40(10):743-5. doi: 10.1111/j.2042-7158.1988.tb07010.x.

Abstract

The IC50 values for the in-vitro inhibition of the prostaglandin synthetase (bovine seminal vesicle mitochondrial fraction) mediated PGE2 production from arachidonic acid by parthenolide, michefuscalide and chrysanthenyl acetate were 11.0 +/- 0.44, 12.1 +/- 0.51 and 14.2 +/- 0.58 microM (mean +/- 95% confidence limits), respectively.

MeSH terms

  • Bridged Bicyclo Compounds / isolation & purification
  • Bridged Bicyclo Compounds / metabolism
  • Cyclooxygenase Inhibitors*
  • Monoterpenes*
  • Plants, Medicinal / analysis*
  • Prostaglandins / biosynthesis
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / metabolism
  • Sesquiterpenes / pharmacology

Substances

  • Bridged Bicyclo Compounds
  • Cyclooxygenase Inhibitors
  • Monoterpenes
  • Prostaglandins
  • Sesquiterpenes
  • parthenolide
  • chrysanthenyl acetate
  • michefucscalide