Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases

doi:10.1097/PAS.0000000000000972

. 2018 Feb;42(2):234-246.

doi: 10.1097/PAS.0000000000000972.

Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases

Alena Skalova^{1

2}, Tomas Vanecek³, Petr Martinek³, Ilan Weinreb⁴, Todd M Stevens⁵, Roderick H W Simpson⁶, Martin Hyrcza⁷, Niels J Rupp⁸, Martina Baneckova^{1

2}, Michael Michal Jr^{1

9}, David Slouka¹⁰, Tomas Svoboda¹¹, Alena Metelkova¹², Arghavan Etebarian¹³, Jaroslav Pavelka^{3

14}, Steven J Potts¹⁵, Jason Christiansen¹⁵, Petr Steiner^{1

3}, Michal Michal¹

Affiliations

¹ Departments of Pathology.
² Bioptic Laboratory Ltd.
³ Bioptic Laboratory Ltd, Molecular Pathology Laboratory.
⁴ Department of Pathology, University Health Network, Toronto, ON, Canada.
⁵ Department of Pathology, University of Alabama at Birmingham, Birmingham, AL.
⁶ Department of Anatomical Pathology, University of Calgary and Foothills Medical Centre, Calgary, AB.
⁷ Department of Pathology and Molecular Medicine, St. Joseph's Healthcare & Hamilton Health Sciences, McMaster University, Vancouver, BC, Canada.
⁸ Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
⁹ Biomedical Center, Faculty of Medicine in Pilsen, Charles University.
¹⁰ Otorhinolaryngology.
¹¹ Oncology and Radiotherapy, Oncological Clinic.
¹² Clinical Oncology, Oncological Clinic, Faculty of Medicine in Plzen.
¹³ Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
¹⁴ Faculty of Education, University of West Bohemia, Plzen, Czech Republic.
¹⁵ Ignyta Inc. San Diego, California, United States.

PMID: 29076873
DOI: 10.1097/PAS.0000000000000972

Free article

Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases

Alena Skalova et al. Am J Surg Pathol. 2018 Feb.

Free article

. 2018 Feb;42(2):234-246.

doi: 10.1097/PAS.0000000000000972.

Authors

Affiliations

¹ Departments of Pathology.
² Bioptic Laboratory Ltd.
³ Bioptic Laboratory Ltd, Molecular Pathology Laboratory.
⁴ Department of Pathology, University Health Network, Toronto, ON, Canada.
⁵ Department of Pathology, University of Alabama at Birmingham, Birmingham, AL.
⁶ Department of Anatomical Pathology, University of Calgary and Foothills Medical Centre, Calgary, AB.
⁷ Department of Pathology and Molecular Medicine, St. Joseph's Healthcare & Hamilton Health Sciences, McMaster University, Vancouver, BC, Canada.
⁸ Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
⁹ Biomedical Center, Faculty of Medicine in Pilsen, Charles University.
¹⁰ Otorhinolaryngology.
¹¹ Oncology and Radiotherapy, Oncological Clinic.
¹² Clinical Oncology, Oncological Clinic, Faculty of Medicine in Plzen.
¹³ Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
¹⁴ Faculty of Education, University of West Bohemia, Plzen, Czech Republic.
¹⁵ Ignyta Inc. San Diego, California, United States.

PMID: 29076873
DOI: 10.1097/PAS.0000000000000972

Abstract

ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation.

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The ETV6-RET Gene Fusion Is Found in ETV6-rearranged Low-grade Sinonasal Adenocarcinoma Without NTRK3 Involvement.
Andreasen S, Kiss K, Melchior LC, Laco J. Andreasen S, et al. Am J Surg Pathol. 2018 Jul;42(7):985-988. doi: 10.1097/PAS.0000000000001069. Am J Surg Pathol. 2018. PMID: 29683817 No abstract available.

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Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases

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Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases

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