Intracardiac Metastases Detected by 18F-FSPG PET/CT

Clin Nucl Med. 2018 Jan;43(1):28-30. doi: 10.1097/RLU.0000000000001883.


PET/CT imaging is frequently used for cancer diagnosis and restaging as metabolically active cells, including cancer, utilize glucose for proliferation. F-FDG is the most commonly utilized radiopharmaceutical in PET/CT imaging. Limitations of F-FDG imaging include intense physiologic uptake in benign tissues such as the brain and myocardium. We present a case of non-small cell lung cancer with myocardial and pericardial metastases obscured by physiologic F-FDG cardiac uptake but detected with the investigational PET radiotracer (4S)-4-(3-F-fluoropropyl)-L-glutamate (F-FSPG), which targets a pathway associated with glutathione biosynthesis. This case demonstrates the added value of F-FSPG PET/CT imaging.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / pathology
  • Female
  • Glutamates* / metabolism
  • Heart Neoplasms / diagnostic imaging*
  • Heart Neoplasms / metabolism
  • Heart Neoplasms / secondary*
  • Humans
  • Lung Neoplasms / pathology
  • Middle Aged
  • Positron Emission Tomography Computed Tomography*


  • 4-(3-fluoropropyl)glutamic acid
  • Glutamates