Recovery Effects of Oral Administration of Glucosylceramide and Beet Extract on Skin Barrier Destruction by UVB in Hairless Mice

Nutrients. 2017 Oct 27;9(11):1178. doi: 10.3390/nu9111178.


Purified glucosylceramide from beet extract (beet GlcCer) and beet extract containing an equal amount of GlcCer were administered orally to ultra violet B (UVB)-irradiated mice, and differences in the protective effects against skin barrier dysfunction caused by UVB irradiation were compared. In the beet GlcCer group, epidermal thickening and the decrease in stratum corneum (SC) ceramide content caused by UVB irradiation were reduced. In the group that was orally administered beet extract containing glucosylceramide, effects similar to those in the beet GlcCer group were observed. Oral administration of beet GlcCer had no obvious effects against an increase in TEWL or decrease in SC water content after UVB irradiation, but there was improvement in the beet extract group. Oral administration of beet GlcCer is effective in improving skin barrier function in UVB-irradiated mice. Beet extract contains constituents other than GlcCer that are also effective in improving skin barrier function.

Keywords: beet; glucosylceramide; oral administration; skin barrier; ultra violet.

MeSH terms

  • Administration, Oral
  • Animals
  • Beta vulgaris / chemistry*
  • Ceramides / metabolism
  • Epidermis / drug effects
  • Epidermis / radiation effects
  • Glucosylceramides / pharmacology*
  • Male
  • Mice, Hairless
  • Plant Extracts / pharmacology*
  • Skin / drug effects*
  • Skin / metabolism
  • Skin / radiation effects
  • Skin Diseases / etiology
  • Skin Diseases / metabolism
  • Skin Diseases / prevention & control
  • Ultraviolet Rays / adverse effects*


  • Ceramides
  • Glucosylceramides
  • Plant Extracts