Enterotoxigenic Escherichia coli targeting intestinal epithelial tight junctions: An effective way to alter the barrier integrity

Abstract

Enterotoxigenic Escherichia coli are responsible for causing secretory diarrhea in animal(s), including human(s). This group of microorganisms is classified on the basis of production of toxins acting on the intestinal epithelium of the small intestine. Various enterotoxins, heat-labile and heat-resistant, are produced by distinct strains of ETEC. Although the mechanisms of action of ETEC enterotoxins were shown to involve diverse ion channels recent data suggest that these molecules could also be involved in disruption of the permeability barrier of the intestinal epithelium. More precisely, the tight junctions directly responsible for the selective permeability of the intestinal tissue could be affected. Studies indicating a change in TJ following exposure of cell monolayers or animal models either to pure enterotoxins or to ETEC strains producing one or more of these toxic molecules will be discussed.

Keywords: Diarrhea; Enterotoxins; Epithelium; Escherichia coli; Paracellular pathway; Small intestine; Tight junctions.