Lactobacillus plantarum C29 Alleviates TNBS-Induced Memory Impairment in Mice

J Microbiol Biotechnol. 2018 Jan 28;28(1):175-179. doi: 10.4014/jmb.1709.09042.


In a preliminary study, Lactobacillus plantarum C29 was found to suppress 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Therefore, to understand whether an anti-colitic probiotic C29 could attenuate memory impairment, we examined the effects of C29 on TNBS-induced memory impairment in mice. Orally administered Lactobacillus plantarum C29 attenuated TNBS-induced memory impairment in mice in the Y-maze, noble object, and passive avoidance task tests. C29 treatment increased TNBS-suppressed hippocampal brain-derived neurotrophic factor expression and inhibited TNBS-induced hippocampal NF-kappaB activation and blood LPS levels. Moreover, C29 restored the TNBS-disturbed gut microbiota composition. These findings suggest that C29 can alleviate memory impairment presumably by restoring the gut microbiota composition.

Keywords: Lactobacillus plantarum; colitis; gut microbiota; memory impairment.

MeSH terms

  • Administration, Oral
  • Animals
  • Lactobacillus plantarum / metabolism*
  • Male
  • Memory Disorders / chemically induced*
  • Memory Disorders / prevention & control*
  • Mice, Inbred C57BL
  • Probiotics / administration & dosage*
  • Treatment Outcome
  • Trinitrobenzenesulfonic Acid / toxicity*


  • Trinitrobenzenesulfonic Acid