Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment

J Lee; S W Seo; J-J Yang; Y K Jang; J S Lee; Y J Kim; J Chin; J M Lee; S T Kim; K-H Lee; J H Lee; J S Kim; S Kim; H Yoo; A Y Lee; D L Na; H J Kim

doi:10.1111/ene.13500

Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment

Eur J Neurol. 2018 Feb;25(2):326-333. doi: 10.1111/ene.13500. Epub 2017 Dec 21.

Authors

J Lee^{1

2

3}, S W Seo^{2

3

4

5}, J-J Yang⁶, Y K Jang^{2

3}, J S Lee⁷, Y J Kim^{2

3

8}, J Chin^{2

3}, J M Lee⁶, S T Kim⁹, K-H Lee¹⁰, J H Lee¹¹, J S Kim¹², S Kim¹³, H Yoo¹³, A Y Lee¹, D L Na^{2

3

4}, H J Kim^{2

3}

Affiliations

¹ Department of Neurology, Chungnam National University Hospital, Daejeon, Korea.
² Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
³ Neuroscience Center, Samsung Medical Center, Seoul, Korea.
⁴ Department of Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea.
⁵ Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea.
⁶ Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
⁷ Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
⁸ Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Gangwon-do, Korea.
⁹ Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
¹⁰ Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
¹¹ Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
¹² Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
¹³ Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea.

PMID: 29082576
DOI: 10.1111/ene.13500

Abstract

Background and purpose: Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients.

Methods: Seventy-two svMCI patients were divided into early stage (ES-svMCI, n = 39) and late stage (LS-svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [¹¹ C] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months.

Results: There was no difference in the rate of increase in PiB uptake or lacune number between the ES-svMCI and LS-svMCI. However, LS-svMCI showed more rapid cortical thinning and cognitive decline than did the ES-svMCI.

Conclusions: We suggest that, whilst the rate of change in pathological burden did not differ between ES-svMCI and LS-svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS-svMCI.

Keywords: cognition; cortical thickness; early stage; late stage; subcortical vascular mild cognitive impairment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Cerebral Cortex / diagnostic imaging*
Cerebral Small Vessel Diseases / complications
Cerebral Small Vessel Diseases / diagnostic imaging*
Cognitive Dysfunction / etiology
Cognitive Dysfunction / physiopathology*
Disease Progression*
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging / methods
Male
Neuropsychological Tests
Positron-Emission Tomography / methods