Digitalis Toxicity

Book
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
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Excerpt

Digoxin is a well-known cardiac glycoside and one of the oldest drugs used today in cardiovascular medicine. It has wide-ranging beneficial effects and continues to play an important role in the contemporary management of appropriately selected patients with heart failure and atrial fibrillation. Although considered safe, digoxin has a narrow therapeutic window, and its proper dosing requires the clinician to be mindful of various patient characteristics including age, gender, kidney function and concomitant use of other drugs to avoid potentially life-threatening toxicity.

Over the past two decades, the use of digoxin has declined significantly and toxicity cases cases are rare. The few sporadic cases are often managed with digoxin specific antigen binding antibody.

Publication types

  • Study Guide