Tranylcypromine

Excerpt

Tranylcypromine is a monoamine oxidase inhibitor FDA-approved for the treatment of major depressive disorder without melancholia. Off-label uses include treatment-resistant depression, treatment-resistant social anxiety disorder, treatment-resistant panic disorder, and atypical depression. This activity reviews the indications, mechanism of action, administration methods, significant adverse effects, contraindications, toxicity, and monitoring requirements for tranylcypromine. Emphasis is placed on the recognition and management of key drug-drug interactions and boxed warnings, such as the risks of hypertensive crisis and serotonin syndrome.