In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.


Fluoxetine is an FDA-approved medication that has demonstrated efficacy in treating a spectrum of psychological conditions. These indications include major depressive disorder, obsessive-compulsive disorder, panic disorder, bulimia, binge eating disorder, premenstrual dysphoric disorder, and bipolar depression, including cases of treatment-resistant depression when combined with olanzapine. The mechanism of action involves the inhibition of serotonin reuptake in presynaptic neurons, achieved by blocking the reuptake transporter protein. This activity provides insights into fluoxetine's indications, off-label uses, mechanism of action, dosing, adverse effects, contraindications, monitoring, and toxicity.

Publication types

  • Study Guide