Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Oct 23;43(256):149-153.

[Morphological and Immunological Variation of Borrelia Burgdorferi and Diagnostic Methods]

[Article in Polish]
Affiliations
  • PMID: 29084186
Editorial

[Morphological and Immunological Variation of Borrelia Burgdorferi and Diagnostic Methods]

[Article in Polish]
Tadeusz Płusa. Pol Merkur Lekarski. .

Abstract

Diagnostic problems observed in patients infected with Borrelia burgdorferi are a significant impediment to therapeutic decision making. It appears that the pathogen is characterized by morphological and immunological variation in particular stages of development. The bacterium has the ability to morphologically transform into a cell wall deficient form of spheroplast, L-form, bleb-like spirochetes and round body/form cysts. It also has the ability to create biofilm, which is a major barrier to antibiotics. Bacteria are characterized by significant heterogeneity and antigen polymorphism, which greatly hampers the detailed definition of the pathogen, since the antibodies produced may differ significantly from the accepted patterns and also lead to cross reactions. The above conditions affect the reliability of diagnostic tests, especially screening, which may lead to wrong therapeutic decisions.

Keywords: antigens; biofilm; borreliosis; diagnostics.

Similar articles

See all similar articles

Publication types

MeSH terms

Substances

LinkOut - more resources

Feedback