Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility

Nat Plants. 2017 Nov;3(11):854-858. doi: 10.1038/s41477-017-0039-z. Epub 2017 Oct 30.


The outermost cell layer of plant roots (epidermis) constantly encounters environmental challenges. The epidermal outer plasma membrane domain harbours the PENETRATION3 (PEN3)/ABCG36/PDR8 ATP-binding cassette transporter that confers non-host resistance to several pathogens. Here, we show that the Arabidopsis ENDOPLASMIC RETICULUM-ARRESTED PEN3 (EAP3) BTB/POZ-domain protein specifically mediates PEN3 exit from the endoplasmic reticulum and confers resistance to a root-penetrating fungus, providing prime evidence for BTB/POZ-domain protein-dependent membrane trafficking underlying disease resistance.

MeSH terms

  • ATP-Binding Cassette Transporters / metabolism*
  • Arabidopsis / genetics
  • Arabidopsis / metabolism*
  • Arabidopsis / microbiology*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism*
  • Chromosome Mapping
  • Chromosomes, Plant
  • Endoplasmic Reticulum / metabolism
  • Green Fluorescent Proteins / genetics
  • Membrane Proteins / metabolism
  • Mutation
  • Plant Roots / metabolism
  • Plant Roots / microbiology
  • Protein Domains


  • ATP-Binding Cassette Transporters
  • Arabidopsis Proteins
  • Membrane Proteins
  • PDR8 protein, Arabidopsis
  • Green Fluorescent Proteins