Subunit structure and enzymic activity of pertussis toxin

Microbiol Sci. 1988 Sep;5(9):285-7.

Abstract

Pertussis toxin, an ADP-ribosylating toxin, interacts with vertebrate cells of many types and inhibits the ability of these cells to respond to certain hormones and neurotransmitters, resulting in a multitude of biological effects. The structure and mechanism of action of this toxin are described.

Publication types

  • Review

MeSH terms

  • Animals
  • Bordetella pertussis / enzymology
  • Bordetella pertussis / metabolism*
  • Pertussis Toxin*
  • Poly(ADP-ribose) Polymerases / metabolism*
  • Structure-Activity Relationship
  • Virulence Factors, Bordetella / metabolism*

Substances

  • Virulence Factors, Bordetella
  • Poly(ADP-ribose) Polymerases
  • Pertussis Toxin