Preservation of hand movement representation in the sensorimotor areas of amputees

Brain. 2017 Dec 1;140(12):3166-3178. doi: 10.1093/brain/awx274.

Abstract

Denervation due to amputation is known to induce cortical reorganization in the sensorimotor cortex. Although there is evidence that reorganization does not lead to a complete loss of the representation of the phantom limb, it is unclear to what extent detailed, finger-specific activation patterns are preserved in motor cortex, an issue that is also relevant for development of brain-computer interface solutions for paralysed people. We applied machine learning to obtain a quantitative measure for the functional organization within the motor and adjacent cortices in amputees, using high resolution functional MRI and attempted hand gestures. Subjects with above-elbow arm amputation (n = 8) and non-amputated controls (n = 9) made several gestures with either their right or left hand. Amputees attempted to make gestures with their amputated hand. Images were acquired using 7 T functional MRI. The sensorimotor cortex was divided into four regions, and activity patterns were classified in individual subjects using a support vector machine. Classification scores were significantly above chance for all subjects and all hands, and were highly similar between amputees and controls in most regions. Decodability of phantom movements from primary motor cortex reached the levels of right hand movements in controls. Attempted movements were successfully decoded from primary sensory cortex in amputees, albeit lower than in controls but well above chance level despite absence of somatosensory feedback. There was no significant correlation between decodability and years since amputation, or age. The ability to decode attempted gestures demonstrates that the detailed hand representation is preserved in motor cortex and adjacent regions after denervation. This encourages targeting sensorimotor activity patterns for development of brain-computer interfaces.

Keywords: amputee; functional MRI; hand representation; sensorimotor cortex.

MeSH terms

  • Adult
  • Aged
  • Amputation*
  • Case-Control Studies
  • Female
  • Forearm*
  • Functional Neuroimaging
  • Hand*
  • Humans
  • Machine Learning*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Motor Cortex / physiopathology*
  • Phantom Limb / physiopathology*
  • Sensorimotor Cortex / physiopathology
  • Time Factors
  • Young Adult