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. 2017 Aug 24;8(43):75516-75527.
doi: 10.18632/oncotarget.20466. eCollection 2017 Sep 26.

TACC3 as an independent prognostic marker for solid tumors: a systematic review and meta-analysis

June Wang  1   2 , Shenlin Du  2 , Wei Fan  1   3 , Ping Wang  1 , Weiqing Yang  2 , Mingxia Yu  1
Affiliations

TACC3 as an independent prognostic marker for solid tumors: a systematic review and meta-analysis

June Wang et al. Oncotarget. .

Abstract

Recent studies have showed that the transforming acidic coiled coil 3 (TACC3), was aberrantly up-regulated in various solid tumors and was reported to be correlated with unfavorable prognosis in cancer patients. This study aimed to examine the relationship between TACC3 and relevant clinical outcomes. Pubmed, Web of Science, Embase and Cochrane Library were systematically searched to obtain all eligible articles. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the influence of TACC3 expression on overall survival (OS) and disease-free survival (DFS) in solid tumors patients. A total of 1943 patients from 11 articles were included. The result indicated that a significantly shorter OS was observed in patients with high expression level of TACC3 (HR=1.90, 95% CI=1.63-2.23). In the subgroup analysis, the association was also observed in patients with cancers of digestive system (HR=1.85, 95% CI=1.53-2.24). Statistical significance was also observed in subgroup meta-analysis stratified by the cancer type, analysis type and sample size. Furthermore, poorer DFS was observed in patients with high expression level of TACC3 (HR=2.67, 95% CI=2.10-3.40). Additionally, the pooled odds ratios (ORs) showed that increased TACC3 expression was also related to positive lymph node metastasis (OR=1.68, 95% CI=1.26-2.25), tumor differentiation (OR=1.90, 95% CI=1.25-2.88) and TNM stage (OR=1.66, 95% CI=1.25-2.20). In conclusion, the increased expression level of TACC3 was associated with unfavorable prognosis, suggesting that it was a valuable prognosis biomarker or a promising therapeutic target of solid tumors. Further studies should be conducted to confirm the clinical utility of TACC3 in human solid tumors.

Keywords: TACC3; meta-analysis; prognosis; solid tumors; survival.

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Figures

Figure 1
Figure 1. The flow diagram of the selection process in the meta-analysis
Figure 2
Figure 2. Forest plot of HR for the correlation between TACC3 expression and overall survival (OS) in solid tumor
Figure 3
Figure 3. Forest plot of HR for the correlation between TACC3 expression and disease-free survival (DFS) in solid tumor
Figure 4
Figure 4. Forest plots of odds ratios (OR) for the association between TACC3 overexpression and clinicopathological features in cancer patients
(A) lymph node metastases; (B) TNM stage; (C) tumor differentiation.
Figure 5
Figure 5. Sensitivity analysis of the meta-analysis
(A) Overall survival(OS). (B) Disease-free survival (DFS).
Figure 6
Figure 6. Begg’s funnel plots for the studies involved in the meta-analysis of TACC3 expression and the prognosis of patients with solid tumors
(A) Overall survival. (B) Disease-free survival. loghr, logarithm of hazard ratios; s.e., standard error.
See this image and copyright information in PMC

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