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Prognostic Analysis of Radical Resection for Intrahepatic Cholangiocarcinoma: A Retrospective Cohort Study

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Prognostic Analysis of Radical Resection for Intrahepatic Cholangiocarcinoma: A Retrospective Cohort Study

Qingqiang Ni et al. Oncotarget.

Abstract

The aim of this study was to investigate the relationship between the clinicopathological characteristics of intrahepatic cholangiocarcinoma (ICC) and both disease-free survival (DFS) and overall survival (OS) in intrahepatic cholangiocarcinoma (ICC) patients who underwent radical resection (R0). We retrospectively analyzed the clinicopathological characteristics of 319 patients who underwent radical resection of ICC between October 1999 and December 2003. The independent adverse prognostic factors that affected DFS after radical resection of ICC were as follows: maximum tumor diameter (HR = 1.330, P = 0.014), complicated bile duct stone (HR = 1.923, P = 0.013), macroscopic tumor thrombus (HR = 1.826, P = 0.009), and lymph node metastasis (Pathology N1) (HR = 2.330, P = 0.005) were independent adverse prognostic factors that affected the DFS after radical resection of ICC. The postoperative median DFS was 6 months. The independent adverse prognostic factors that affected OS after radical resection of ICC were as follows: maximum tumor diameter (HR = 1.326, P = 0.014), complicated bile duct stone (HR = 2.349, P = 0.001), and lymph node metastasis (Pathology N1) (HR = 2.420, P = 0.003). The postoperative median survival time was 22 months, the 3-year survival rate was 33.9%, and the 5-year survival rate was 23.2%. Macroscopic tumor thrombus (OR = 2.991, P = 0.004) was an independent risk factor for death within 1 year after radical resection.

Keywords: disease-free survival; intrahepatic cholangiocarcinoma; overall survival; radical resection; retrospective cohort study.

Conflict of interest statement

CONFLICTS OF INTEREST No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

Figures

Figure 1
Figure 1
A. DFS curves; B. OS curves.
Figure 2
Figure 2. The survival comparison of independent prognostic factors using the log-rank method: maximum tumor diameter
A., complicated bile duct stone B., and lymph node metastasis (Pathology N1) C..

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