Change in Nonhigh-Density Lipoprotein Cholesterol Levels in Adults With Prediabetes

Medicine (Baltimore). 2017 Nov;96(44):e8461. doi: 10.1097/MD.0000000000008461.

Abstract

This study aimed to observe the change in nonhigh-density lipoprotein cholesterol (non-HDL-C) levels and analyzed its related factors in adults with prediabetes (impaired fasting glucose and/or impaired glucose tolerance).This case-controlled study included 56 adults with normal glucose tolerance (NGT) and 74 adults with prediabetes. The cases and controls were age and gender-matched. Anthropometric measurements including height, weight, waist circumference, and blood pressure were performed. All patients underwent an oral glucose tolerance test (OGTT) after 8 hours of fasting, and the levels of glucose, insulin, lipids, and uric acid were measured.The levels of non-HDL-C (3.63 ± 0.92 vs 3.27 ± 1.00 mmol/L) were significantly higher in prediabetic subjects than in NGT subjects (P < .05). Non-HDL-C positively correlated with HOMA-IR (r = 0.253, P = .004), triglyceride (r = 0.204, P = .020), and uric acid (r = 0.487, P = .000). After multivariate analysis, uric acid continued to be significantly associated with non-HDL-C (β = 0.006, P = .000).Non-HDL-C is elevated in adults with prediabetes. A relationship between non-HDL-C and uric acid was observed.

MeSH terms

  • Adult
  • Anthropometry
  • Blood Glucose / analysis*
  • Blood Pressure
  • Body Height
  • Body Weight
  • Case-Control Studies
  • Cholesterol / blood*
  • Fasting / blood
  • Female
  • Glucose Intolerance / blood*
  • Glucose Intolerance / etiology
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood
  • Lipids / blood
  • Lipoproteins / blood*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Prediabetic State / blood*
  • Prediabetic State / complications
  • Uric Acid / blood
  • Waist Circumference

Substances

  • Blood Glucose
  • Insulin
  • Lipids
  • Lipoproteins
  • lipoprotein cholesterol
  • Uric Acid
  • Cholesterol