Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer

L M Sollid; G Markussen; J Ek; H Gjerde; F Vartdal; E Thorsby

doi:10.1084/jem.169.1.345

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer

J Exp Med. 1989 Jan 1;169(1):345-50. doi: 10.1084/jem.169.1.345.

Authors

L M Sollid¹, G Markussen, J Ek, H Gjerde, F Vartdal, E Thorsby

Affiliation

¹ Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

Abstract

Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Celiac Disease / genetics*
HLA-DQ Antigens / genetics*
Haplotypes
Humans
Oligonucleotide Probes

Substances

HLA-DQ Antigens
Oligonucleotide Probes