Ziziphus Jujube: a review study of its anticancer effects in various tumor models invitro and invivo

Cell Mol Biol (Noisy-le-grand). 2017 Oct 31;63(10):122-127. doi: 10.14715/cmb/2017.63.10.19.


The growing rate of cancer incidences and inefficiency of current therapies have made scientists to find novel agents such as medicinal plants. Ziziphus jujube is one of these plants whose pharmaceutical effects have been studied for a long time. Recent investigations have proved that bioactive compounds of Ziziphus jujube including triterpenic acids, flavonoids, cerebrosides, phenolic acids, α tocopherol, β carotene, and polysaccharides have anti-proliferative effects on several cancerous cell lines and animals. The present study aimed to cover all previous invitro and invivo findings and some of molecular mechanisms of its anticancer property.

Keywords: Cancer; IC50.; Invitro; Invivo; Molecular mechanism; Ziziphus jujube.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Antineoplastic Agents, Phytogenic / toxicity
  • Apoptosis / drug effects
  • Cell Cycle Checkpoints / drug effects
  • Cell Proliferation / drug effects
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use*
  • Plant Extracts / toxicity
  • Transplantation, Heterologous
  • Ziziphus / chemistry*
  • Ziziphus / metabolism


  • Antineoplastic Agents, Phytogenic
  • Plant Extracts