ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians: an update meta-analysis

Cell Mol Biol (Noisy-le-grand). 2017 Oct 31;63(10):137-140. doi: 10.14715/cmb/2017.63.10.22.

Abstract

Some reports evaluated the association between ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians. The results remained unknown. Thus, we did a meta-analysis to evaluate this association. Nine case-control studies with 4198 patients and 3699 controls were included in this meta-analysis. A significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in Caucasians (OR=1.18; 95%CI, 1.08-1.28; P=0.0002). ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians from Europe (OR=1.20; 95%CI, 1.09-1.32; P=0.0002) but not from other countries (OR=1.13; 95%CI, 0.95-1.36; P=0.17). No significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in males (OR=1.12; 95%CI, 0.91-1.39; P=0.28). Moreover, ALOX5AP rs10507391 polymorphism was not associated with cardioembolic ischemic stroke risk (OR=1.04; 95%CI, 0.73-1.48; P=0.84). In conclusion, this study found that ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians.

Keywords: ALOX5AP; Genetic; Ischemic stroke; Polymorphism..

Publication types

  • Meta-Analysis

MeSH terms

  • 5-Lipoxygenase-Activating Proteins / genetics*
  • Case-Control Studies
  • Databases, Factual
  • Genetic Predisposition to Disease
  • Humans
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Sex Factors
  • Stroke / genetics*
  • Stroke / pathology
  • White People / genetics*

Substances

  • 5-Lipoxygenase-Activating Proteins
  • ALOX5AP protein, human