Analysis of lipid metabolism and its impact on the risk of ischemic heart disease in patients with definite familial hypercholesterolemia

Atheroscler Suppl. 2017 Nov:30:56-62. doi: 10.1016/j.atherosclerosissup.2017.05.008. Epub 2017 Jun 1.

Abstract

Aim: to analyze the relationship between lipid disturbance, including lipoprotein(a) (Lp(a)) levels, and development of ischemic heart disease (IHD) in patients with familial hypercholesterolemia (FH).

Materials and methods: 81 patients (middle age was 39.1 ± 0.4 years, 33 males, 48 females) with a definite FH were examined. The concentration of Lp(a) was determined by immunoturbidimetric method. Lipid profiles were estimated by enzymatic colorimetric method.

Results: Lp(a) levels were elevated in 41.9% of FH patients. In FH patients with elevated Lp(a) (>0.3 g/l) IHD occurred 1.7 times more often, myocardial infarction - 2.76 times. The risk of IHD in FH patients was increased in individuals with Lp(a) 1.2 g/l and above.

Conclusion: Lp(a) elevation plays an additional role in IHD appearance in FH.

Keywords: Familial hypercholesterolemia; Ischemic heart disease; Lipoprotein(a).

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers / blood
  • Female
  • Humans
  • Hyperlipoproteinemia Type II / blood*
  • Hyperlipoproteinemia Type II / diagnosis
  • Hyperlipoproteinemia Type II / epidemiology*
  • Hyperlipoproteinemia Type II / genetics
  • Incidence
  • Lipid Metabolism*
  • Lipoprotein(a) / blood*
  • Male
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / epidemiology
  • Myocardial Ischemia / blood*
  • Myocardial Ischemia / diagnosis
  • Myocardial Ischemia / epidemiology*
  • Myocardial Ischemia / genetics
  • Prognosis
  • Registries
  • Risk Assessment
  • Risk Factors
  • Russia / epidemiology
  • Up-Regulation
  • Young Adult

Substances

  • Biomarkers
  • Lipoprotein(a)