Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes

Diabetes Res Clin Pract. 2018 Jan:135:7-10. doi: 10.1016/j.diabres.2017.10.005. Epub 2017 Oct 31.


We analyzed circulating Meteorin-like (METRNL) levels in human. Serum METRNL levels were significantly lower in subjects with diabetes mellitus compared with those without diabetes. Serum METRNL was negatively correlated with the serum glucose level and insulin resistance. Metformin treatment did not increase the serum METRL levels after 12 weeks.

Keywords: Diabetes mellitus; Insulin resistance; Meteorin-like.

MeSH terms

  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / diagnosis
  • Female
  • Humans
  • Insulin / blood*
  • Insulin Resistance / physiology*
  • Intercellular Signaling Peptides and Proteins / blood*
  • Male
  • Metformin / therapeutic use
  • Middle Aged
  • Nerve Tissue Proteins / blood*


  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • METRN protein, human
  • Nerve Tissue Proteins
  • Metformin