Draft genome sequence of the Wolbachia endosymbiont of Wuchereria bancrofti wWb

Pathog Dis. 2017 Dec 29;75(9):ftx115. doi: 10.1093/femspd/ftx115.


The draft genome assembly of the Wolbachia endosymbiont of Wuchereria bancrofti (wWb) consists of 1060 850 bp in 100 contigs and contains 961 ORFs, with a single copy of the 5S rRNA, 16S rRNA and 23S rRNA and each of the 34 tRNA genes. Phylogenetic core genome analyses show wWb to cluster with other strains in supergroup D of the Wolbachia phylogeny, while being most closely related to the Wolbachia endosymbiont of Brugia malayi strain TRS (wBm). The wWb and wBm genomes share 779 orthologous clusters with wWb having 101 unclustered genes and wBm having 23 unclustered genes. The higher number of unclustered genes in the wWb genome likely reflects the fragmentation of the draft genome.

Keywords: Wolbachia; Wuchereria bancrofti; endosymbiont; genomics; lymphatic filariasis; nematode.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cluster Analysis
  • Genes, rRNA
  • Genome, Bacterial*
  • Open Reading Frames
  • Phylogeny
  • RNA, Ribosomal, 16S / genetics
  • RNA, Ribosomal, 23S / genetics
  • RNA, Ribosomal, 5S / genetics
  • Sequence Analysis, DNA*
  • Wolbachia / genetics*
  • Wolbachia / isolation & purification
  • Wuchereria bancrofti / microbiology*


  • RNA, Ribosomal, 16S
  • RNA, Ribosomal, 23S
  • RNA, Ribosomal, 5S