Vitamin C: C-ing a New Way to Fight Leukemia

Cell Stem Cell. 2017 Nov 2;21(5):561-563. doi: 10.1016/j.stem.2017.09.015.


Metabolic cues and (epi-)genetic factors are emerging regulators of hematopoietic stem cell (HSC) potency. Two new studies in Nature and Cell, from Agathocleous et al. (2017) and Cimmino et al. (2017), respectively, show that vitamin C regulates HSC function and suppresses leukemogenesis by modulating Tet2 activity.

Publication types

  • Comment

MeSH terms

  • Ascorbic Acid*
  • DNA-Binding Proteins
  • Dioxygenases
  • Disease Progression
  • Hematopoietic Stem Cells
  • Humans
  • Leukemia*
  • Proto-Oncogene Proteins


  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Dioxygenases
  • TET2 protein, human
  • Ascorbic Acid