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The Role of Substance P in Epilepsy and Seizure Disorders


The Role of Substance P in Epilepsy and Seizure Disorders

Xue Feng Wang et al. Oncotarget.

Erratum in


A range of evidence implicates the neuropeptide substance P (SP), a member of the tachykinin family, in emotional behavior, anxiety, pain, and inflammation. Recently, SP has been implicated in susceptibility to seizures, for which a potential proconvulsant role was indicated. Indeed, antagonists of a specific SP receptor, neurokinin-1 receptor, were found to attenuate kainic acid (KA)-induced seizure activity. However, detailed mechanisms of SP regulation in epilepsy remain obscure. In this review, we summarize the present literature to expound the role of SP in epilepsy, and provide hypotheses for potential mechanisms.

Keywords: epilepsy; inflammation; neuron; substance P.

Conflict of interest statement

CONFLICTS OF INTEREST The authors confirm that this article content has no conflicts of interest.

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