Nuclear Inositide Signaling and Cell Cycle

Adv Biol Regul. 2018 Jan;67:1-6. doi: 10.1016/j.jbior.2017.10.008. Epub 2017 Oct 23.


Phosphatidylinositols (PIs) are responsible for several signaling pathways related to many cellular functions, such as cell cycle regulation at different check-points, cell proliferation, cell differentiation, membrane trafficking and gene expression. PI metabolism is not only present at the cytoplasmic level, but also at the nuclear one, where different signaling pathways affect essential nuclear mechanisms in eukaryotic cells. In this review we focus on nuclear inositide signaling in relation to cell cycle regulation. Many evidences underline the pivotal role of nuclear inositide signaling in cell cycle regulation and cell proliferation associated to different strategic physiopathological mechanisms in several cell systems and diseases.

Keywords: Cell cycle; Differentiation; Disease; Nucleus; Phosphoinositides; Proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Differentiation / physiology*
  • Cell Nucleus / metabolism*
  • Humans
  • Phosphatidylinositols / metabolism*
  • Signal Transduction / physiology*


  • Phosphatidylinositols