Effect of prescription medications on erectile dysfunction

Postgrad Med J. 2018 Mar;94(1109):171-178. doi: 10.1136/postgradmedj-2017-135233. Epub 2017 Nov 4.


Erectile dysfunction (ED) affects about 50% of men in the USA and is primarily attributed to physiological (organic) and psychological causes. However, a substantial portion of men suffer from ED due to iatrogenic causes. Common medications such as antihypertensives, non-steroidal anti-inflammatory drugs and antacids may cause ED. Physicians should be aware of the various prescription medications that may cause ED to properly screen and counsel patients on an issue that many may feel too uncomfortable to discuss. In this review, we discuss the physiology, data and alternative therapies for the ED caused by medications.

Keywords: ED; erectile dysfunction; iatrogenic ED; iatrogenic erectile dysfunction; medication-induced ED; medication-induced erectile dysfunction.

Publication types

  • Review

MeSH terms

  • Drug-Related Side Effects and Adverse Reactions / prevention & control*
  • Erectile Dysfunction* / chemically induced
  • Erectile Dysfunction* / physiopathology
  • Erectile Dysfunction* / prevention & control
  • Humans
  • Male
  • Practice Patterns, Physicians'
  • Prescription Drugs* / administration & dosage
  • Prescription Drugs* / adverse effects


  • Prescription Drugs