Expanding the Clinical Spectrum of IgLON5-Syndrome

J Neuromuscul Dis. 2017;4(4):337-339. doi: 10.3233/JND-170259.


Anti-IgLON5-syndrome is known to be an antibody-mediated disease that mainly affects central structures in tegmentum and hippocampus and leads to associated symptoms like sleep-related disturbances, parkinsonism, chorea and limb ataxia. This is the first case of a patient with anti-IgLON5-syndrome and generalized fasciculations and neuromyotonic discharges in electromyography, suggesting that a peripheral involvement may occur in anti-Ig-Lon5-syndromes.

Keywords: Neuromyotonia; anti-IgLON5-syndrome; dysphagia; fasciculations; neuroimmunology.

Publication types

  • Case Reports

MeSH terms

  • Autoimmune Diseases of the Nervous System / diagnosis
  • Autoimmune Diseases of the Nervous System / immunology*
  • Autoimmune Diseases of the Nervous System / therapy
  • Cell Adhesion Molecules, Neuronal / immunology*
  • Diagnosis, Differential
  • Fatal Outcome
  • Humans
  • Male
  • Middle Aged
  • Syndrome


  • Cell Adhesion Molecules, Neuronal
  • IgLON5 protein, human