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, 18 (6), 411-418

Effects of Nicomethanol Hydrofluoride on Dental Enamel and Synthetic Apatites: A Role for Anti-Caries Protection


Effects of Nicomethanol Hydrofluoride on Dental Enamel and Synthetic Apatites: A Role for Anti-Caries Protection

N Sharkov. Eur Arch Paediatr Dent.

Erratum in


Aim: To analyse the anti-caries properties of nicomethanol hydrofluoride (NH) and the benefit of its combination with siliglycol, a coating agent.

Methods: Fluoride (F) uptake by dental enamel and synthetic apatite treated with NH was measured in vitro and compared to treatment with mineral fluorides. The addition of siliglycol was also tested. The effect of NH (as a mouthwash) on salivary pH was also investigated in healthy human subjects and compared to the effect of a placebo and of nicomethanol alone.

Results: In vitro experiments showed a greater and faster F uptake on dental enamel or synthetic apatite treated with NH compared to sodium fluoride. F uptake was improved further by the addition of siliglycol. In healthy human subjects, pH reduction was strongly inhibited 5 min after two mouthrinses with NH. This effect was less pronounced but still statistically significant at 15 and 30 min (p < 0.05).

Conclusions: NH was able to promote the fixation of F ions and strengthen the dental structure. Its combination with siliglycol further improved F uptake by the tooth and the control/inhibition of dental biofilm development.

Keywords: Amine fluoride; Caries prevention; Dental caries; Fluorine; Fluorinol®; Siliglycol.

Conflict of interest statement

Conflict of interest

N. Sharkov is a member of the scientific committee held by Pierre Fabre Oral Care.

Ethical approval

Some of the studies have been conducted in the early 1980’s and at that time, in France, ethical approval was not needed.


Fig. 1
Fig. 1
Chemical structure of nicomethanol hydrofluoride (NH)
Fig. 2
Fig. 2
Percentage of fluoride ions (F) bound by variable quantities of synthetic apatite (100 and 200 mg). min minute, NaF sodium fluoride, NH nicomethanol hydrofluoride
Fig. 3
Fig. 3
Fluoridation of synthetic apatite after treatment with solutions of nicomethanol hydrofluoride (NH) and sodium fluoride (NaF): data obtained by infrared spectroscopy. NaF sodium fluoride, NH nicomethanol hydrofluoride
Fig. 4
Fig. 4
Formation of fluoroapatite after treatment with nicomethanol hydrofluoride (NH) and sodium fluoride (NaF). NaF sodium fluoride, NH nicomethanol hydrofluoride
Fig. 5
Fig. 5
Change in salivary pH following two mouthrinses: effect of treatment and time of sampling (5, 15 and 30 min after second mouthrinse). min minute, NH nicomethanol hydrofluoride

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