Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy

Oral Oncol. 2017 Nov:74:40-48. doi: 10.1016/j.oraloncology.2017.09.008. Epub 2017 Sep 21.

Abstract

Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several large single-institution series and national database searches. Recent studies of genomic alterations have helped elucidate the biology and pathogenesis of this aggressive disease. Here we review outcomes of the disease, effects of treatment, prognostic factors, and genomic alterations in SDC. Studies of targeted therapy and promising future directions are also discussed.

Keywords: ErbB2; Salivary duct carcinoma; Salivary malignancy.

Publication types

  • Review
  • Research Support, N.I.H., Intramural

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Mutation
  • Prognosis
  • Salivary Ducts / pathology*
  • Salivary Gland Neoplasms / diagnostic imaging
  • Salivary Gland Neoplasms / genetics
  • Salivary Gland Neoplasms / pathology
  • Salivary Gland Neoplasms / therapy*
  • Survival Analysis