Aim: To compare new remineralizing agents calcium sodium phosphosilicate paste and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste with that of fluoridated toothpaste in remineralization of early carious lesions using scanning electron microscopy and energy-dispersive X-ray (SEM-EDX) analysis.
Materials and methods: Sixty sound extracted premolars were collected and placed in demineralizing solution for 4 days to produce artificial carious lesions. All specimens were evaluated for any loss of mineral content using SEM-EDX analysis. Samples were randomly assigned to three groups: Group I: Fluoridated toothpaste (control), group II: CPP-ACP paste, and group III: Calcium sodium phosphosilicate paste. Specimens were then treated with above-mentioned remineralizing agents and again measured for mineral content using SEM-EDX analysis.
Results: Group III (calcium sodium phosphosilicate paste) showed highest significant difference followed in descending order by group II (CPP-ACP paste) and group I (fluoridated toothpaste).
Conclusion: Calcium sodium phosphosilicate paste showed maximum remineralizing potential compared with CPP-ACP and fluoridated toothpastes.
How to cite this article: Chaudhary I, Tripathi AM, Yadav G, Saha S. Effect of Casein Phosphopeptide-amorphous Calcium Phosphate and Calcium Sodium Phosphosilicate on Artificial Carious Lesions: An in vitro Study. Int J Clin Pediatr Dent 2017;10(3):261-266.
Keywords: Calcium sodium phosphosilicate; Casein phos-phopeptide-amorphous calcium phosphate; Demineralization; Fluoride; Remineralization; Scanning electron microscopy and energy-dispersive X-ray analysis.
Conflict of interest statement
Source of support: Nil Conflict of interest: None
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- Reynolds EC. Calcium phosphate-based remineralization systems: scientific evidence? Aust Dent J. 2008 Sep;53(3):268–273. - PubMed
- Narayana SS, Deepa VK, Ahamed S, Sathish ES, Meyappan R, Satheesh Kumar KS. Remineralization efficiency of bioactive glass on artificially induced carious lesion an in-vitro study. J Indian Soc Pedod Prev Dent. 2014 Feb;32(1):19–25. - PubMed
- Rao A, Malhotra N. The role of remineralizing agents in dentistry: a review. Compend Contin Educ Dent Suppl. 2011 Jul-Aug;32(6):26–33. - PubMed