Investigating metabolic regulation using targeted neuromodulation

Ann N Y Acad Sci. 2018 Jan;1411(1):83-95. doi: 10.1111/nyas.13468. Epub 2017 Nov 6.

Abstract

The central nervous system (CNS) plays a vital role in regulating energy balance and metabolism. Over the last 50 years, studies in animal models have allowed us to identify critical CNS regions involved in these processes and even crucial cell populations. Now, techniques for genetically and anatomically targeted manipulation of specific neural populations using light (optogenetic), ligands (chemogenetic), or magnetic fields (radiogenetic/magnetogenetic) allow detailed investigation of circuits involved in metabolic regulation. In this review, we provide a brief overview of recent studies using light- and magnetic field-regulated neural activity to investigate the neural circuits contributing to metabolic control.

Keywords: feeding; glucose; magnetogenetics; metabolism; optogenetics; radiogenetics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Appetite / drug effects
  • Appetite / physiology
  • Appetite / radiation effects
  • Central Nervous System / physiology*
  • Electromagnetic Fields
  • Energy Metabolism / physiology*
  • Equipment Design
  • Feeding Behavior / drug effects
  • Feeding Behavior / physiology
  • Feeding Behavior / radiation effects
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / radiation effects
  • Glucose / metabolism
  • Homeostasis / physiology
  • Humans
  • Hypothalamus / drug effects
  • Hypothalamus / physiology
  • Ion Channels / chemistry
  • Ion Channels / drug effects
  • Lasers
  • Magnetite Nanoparticles
  • Neurons / drug effects
  • Neurons / radiation effects
  • Optogenetics
  • Protein Engineering
  • Receptors, G-Protein-Coupled / agonists

Substances

  • Ion Channels
  • Magnetite Nanoparticles
  • Receptors, G-Protein-Coupled
  • Glucose