Gestational diabetes - is diet and insulin the only solution?

Neuro Endocrinol Lett. 2017 Oct;38(5):311-315.


Gestational diabetes (GDM) is a relatively common complication of pregnancy. Maternal hyperglycemia causes many serious side effects for mothers, fetuses and newborns. In 90% of women diagnosed with GDM, a dietary treatment results in satisfactory levels of blood glucose. The remaining 10% require insulin therapy to achieve the recommended glycemic levels. The majority of recent studies show the efficiency of metformin in gestational diabetes and prove that it is not a cause for any harmful side effects to the embryo and/or fetus. Metformin is an effective alternative to insulin in glycemic control in pregnant women. The implementation of metformin, as a routine procedure in gestational diabetes, requires further research, the results of which would unequivocally confirm its efficacy and safety for pregnant women and their offspring.

Publication types

  • Review

MeSH terms

  • Blood Glucose / metabolism
  • Diabetes, Gestational / blood
  • Diabetes, Gestational / diet therapy
  • Diabetes, Gestational / drug therapy
  • Diabetes, Gestational / therapy*
  • Diet, Carbohydrate-Restricted*
  • Female
  • Glucose Tolerance Test
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / therapeutic use*
  • Insulin Resistance
  • Metformin / therapeutic use*
  • Pregnancy


  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Metformin