Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 44 (4), 575-585

Focal Ablation of Early-Stage Prostate Cancer: Candidate Selection, Treatment Guidance, and Assessment of Outcome

Affiliations
Review

Focal Ablation of Early-Stage Prostate Cancer: Candidate Selection, Treatment Guidance, and Assessment of Outcome

Eric Edison et al. Urol Clin North Am.

Abstract

Prostate cancer lesions smaller than 0.5 m3, or Gleason pattern 3, are likely clinically insignificant. Clinically significant disease is often limited to a single index lesion. Focal ablation targets this index lesion, maintains oncological control, and minimizes complications by preserving healthy prostate tissue. Template mapping biopsy or multiparametric MRI-targeted biopsies are used to identify appropriate index lesions. Multiple energy modalities have been tested, including high-intensity frequency ultrasound, cryoablation, laser ablation, photodynamic therapy, focal brachytherapy, radiofrequency ablation, irreversible electroporation. Outcome is assessed by biopsy of the target area, triggered by prostate-specific antigen measurements or MRI imaging, or performed per protocol at 12 months.

Keywords: Cryotherapy; High-intensity focused ultrasound ablation; Laser therapy; Photodynamic therapy; Prostate cancer.

Similar articles

See all similar articles

Cited by 1 article

  • Magnetic Resonance-Guided Prostate Ablation.
    Woodrum DA, Kawashima A, Gorny KR, Mynderse LA. Woodrum DA, et al. Semin Intervent Radiol. 2019 Dec;36(5):351-366. doi: 10.1055/s-0039-1697001. Epub 2019 Dec 2. Semin Intervent Radiol. 2019. PMID: 31798208 Review.
Feedback