Prosthetic Replacement of the Ocular Surface Ecosystem Treatment of Ocular Surface Disease After Skull Base Tumor Resection

World Neurosurg. 2018 Feb;110:e124-e128. doi: 10.1016/j.wneu.2017.10.111. Epub 2017 Oct 28.


Background: Prosthetic replacement of the ocular surface ecosystem (PROSE) treatment is an effective, nonsurgical therapeutic option for patients with ocular surface disease related to cranial nerve deficits secondary to skull base tumor resection.

Methods: This case series describes the impact of PROSE treatment in patients with symptomatic exposure keratopathy or neurotrophic keratitis after skull base tumor surgery.

Results: All patients improved symptomatically and functionally with PROSE treatment, and have had sustained improvement for as long as 3 years.

Conclusions: In postneurosurgical cases in which neurologic function may recover, PROSE treatment offers a safe, nonsurgical treatment option to support the ocular surface during the period of observation awaiting neurologic recovery.

Keywords: Neurotrophic keratopathy; PROSE; Skull base tumor surgery.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Contact Lenses*
  • Female
  • Humans
  • Keratitis / etiology*
  • Keratitis / therapy*
  • Middle Aged
  • Postoperative Complications / therapy*
  • Prosthesis Design
  • Skull Base / surgery
  • Skull Base Neoplasms / surgery*