Uterine tumors in ataxia-telangiectasia

Gynecol Oncol. 1989 Feb;32(2):257-60. doi: 10.1016/s0090-8258(89)80045-9.


Roughly one-third of patients with ataxia-telangiectasia (AT) develop malignant tumors, usually of lymphoid origin. AT patients also exhibit progeric changes. We describe three patients, between the ages of 27 and 32 years, with uterine tumors: one with a frank leiomyosarcoma and chronic T-cell leukemia, one with a multilobulated leiomyoma of uncertain malignant potential, and one with an unremarkable leiomyoma. Thus, the spectrum of tumors in AT patients beyond adolescence includes nonlymphoid malignancies and precocious, benign leiomyomas.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Ataxia Telangiectasia / complications*
  • Female
  • Humans
  • Leiomyoma / etiology
  • Leiomyoma / pathology
  • Leiomyosarcoma / etiology
  • Leiomyosarcoma / pathology
  • Leukemia, T-Cell / complications
  • Leukemia, T-Cell / etiology
  • Uterine Neoplasms / etiology*
  • Uterine Neoplasms / pathology