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. 2017 Oct 23;11:76.
doi: 10.3389/fncir.2017.00076. eCollection 2017.

Mechanisms of Long Non-Coding RNAs in the Assembly and Plasticity of Neural Circuitry

Free PMC article

Mechanisms of Long Non-Coding RNAs in the Assembly and Plasticity of Neural Circuitry

Andi Wang et al. Front Neural Circuits. .
Free PMC article


The mechanisms underlying development processes and functional dynamics of neural circuits are far from understood. Long non-coding RNAs (lncRNAs) have emerged as essential players in defining identities of neural cells, and in modulating neural activities. In this review, we summarized latest advances concerning roles and mechanisms of lncRNAs in assembly, maintenance and plasticity of neural circuitry, as well as lncRNAs' implications in neurological disorders. We also discussed technical advances and challenges in studying functions and mechanisms of lncRNAs in neural circuitry. Finally, we proposed that lncRNA studies would advance our understanding on how neural circuits develop and function in physiology and disease conditions.

Keywords: CRISPR-Cas9; cell fates; long non-coding RNA; neural circuit; synaptic plasticity; synaptogenesis.


Figure 1
Figure 1
LncRNAs regulate different aspects of neural circuitry assembly and function (left) via cis- and trans- mechanisms (right). (A–G) LncRNAs can control neurogenesis of neural stem/progenitor cells via regulating expressions of proximal genes (B,E,G) and/or distal genes by associating with fate-determining transcription factors (A–C,E), acting as competing endogenous RNAs (D) and regulating alternative splicing (F). (H) Evf2 controls expression of Dlx5/Dlx6 in cis and Gad1 in trans to regulate GABAergic interneuron specification. (I) LncOL1 interacts with SUZ12 to repress a gene program that maintains oligodendrocyte progenitor state, thereby promoting OL myelination. (J–L) LncRNAs regulate neurite outgrowth and synaptogenesis via cis-regulation (J), alternative splicing (K), and translational control (L).

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