Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 19 (12), 103

The Place of Antipsychotics in the Therapy of Anxiety Disorders and Obsessive-Compulsive Disorders


The Place of Antipsychotics in the Therapy of Anxiety Disorders and Obsessive-Compulsive Disorders

Baptiste Pignon et al. Curr Psychiatry Rep.


Purpose of review: The purpose of this review was to assess and present the findings up to this date on the efficacy of antipsychotics in the treatment of generalized anxiety disorders (GAD), social anxiety disorders (SAD), panic disorders (PD), and obsessive-compulsive disorders (OCD), mostly based on published randomized controlled trials (RCTs) or on open-label studies when RCT were lacking.

Recent findings: Quetiapine could be recommended in patients with GAD. The efficacy of aripiprazole in two open-label studies on patients with antidepressant-refractory GAD should be assessed in RCTs. Despite preliminary positive results in open studies, there are currently no strong evidence for the effectiveness of antipsychotics in refractory SAD and in refractory PD. Conversely, risperidone and aripiprazole can be used for the treatment of refractory OCD as augmentation agents to antidepressants. Contrary to SAD and PD, this review found evidence for the use of second-generation antipsychotics in GAD and OCD. Otherwise, first-generation antipsychotics cannot be recommended in anxiety disorders and OCD.

Keywords: First-generation antipsychotics; Generalized anxiety disorders; Obsessive-compulsive disorders; Panic disorder; Second-generation antipsychotics; Social anxiety disorders.

Similar articles

See all similar articles

Cited by 1 PubMed Central articles


    1. J Affect Disord. 2016 Feb;191:292-9 - PubMed
    1. Expert Opin Investig Drugs. 2015 Apr;24(4):507-17 - PubMed
    1. Clin Ther. 2009 Jun;31(6):1279-308 - PubMed
    1. Clin Ther. 2004 May;26(5):649-66 - PubMed
    1. Arch Gen Psychiatry. 2005 Jun;62(6):593-602 - PubMed

MeSH terms


LinkOut - more resources