Selective Blockade of the Sigma 1 Receptor Has Beneficial Effects on Both Acute and Chronic Oxaliplatin-Induced Peripheral Neuropathy

Neurotherapeutics. 2018 Jan;15(1):176-177. doi: 10.1007/s13311-017-0584-1.
No abstract available

Publication types

  • Editorial

MeSH terms

  • Acute Disease
  • Animals
  • Antineoplastic Agents / adverse effects*
  • Chronic Disease
  • Humans
  • Morpholines / administration & dosage*
  • Oxaliplatin / adverse effects*
  • Peripheral Nervous System Diseases / chemically induced
  • Peripheral Nervous System Diseases / drug therapy*
  • Pyrazoles / administration & dosage*
  • Receptors, sigma / antagonists & inhibitors*
  • Sigma-1 Receptor

Substances

  • 4-(2-((5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl)oxy)ethyl)morpholine
  • Antineoplastic Agents
  • Morpholines
  • Pyrazoles
  • Receptors, sigma
  • Oxaliplatin