Organic CO Prodrugs Activated by Endogenous ROS

Zhixiang Pan; Jun Zhang; Kaili Ji; Vayou Chittavong; Xingyue Ji; Binghe Wang

doi:10.1021/acs.orglett.7b02775

Organic CO Prodrugs Activated by Endogenous ROS

Org Lett. 2018 Jan 5;20(1):8-11. doi: 10.1021/acs.orglett.7b02775. Epub 2017 Nov 7.

Authors

Zhixiang Pan¹, Jun Zhang^{1

2}, Kaili Ji¹, Vayou Chittavong¹, Xingyue Ji¹, Binghe Wang¹

Affiliations

¹ Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University , Atlanta, Georgia 30303 United States.
² Tianjin Medical University , Tianjin 300070, China.

PMID: 29111756
DOI: 10.1021/acs.orglett.7b02775

Abstract

CO prodrugs with triggered release mechanisms are highly desirable for targeted delivery. Herein described are organic CO prodrugs that are activated by ROS and thus can be used to selectively deliver CO to cells with elevated ROS levels. Such CO prodrugs can serve as powerful tools for targeted delivery to disease sites with elevated ROS levels and to explore the therapeutic applications of CO.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems
Molecular Structure
Prodrugs
Reactive Oxygen Species / chemistry*

Substances

Prodrugs
Reactive Oxygen Species