Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families

Nucleic Acids Res. 2018 Jan 4;46(D1):D335-D342. doi: 10.1093/nar/gkx1038.


The Rfam database is a collection of RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. In this paper we introduce Rfam release 13.0, which switches to a new genome-centric approach that annotates a non-redundant set of reference genomes with RNA families. We describe new web interface features including faceted text search and R-scape secondary structure visualizations. We discuss a new literature curation workflow and a pipeline for building families based on RNAcentral. There are 236 new families in release 13.0, bringing the total number of families to 2687. The Rfam website is http://rfam.org.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Nucleic Acid*
  • Genome*
  • Humans
  • Molecular Sequence Annotation
  • Nucleic Acid Conformation
  • RNA, Untranslated / chemistry*
  • RNA, Untranslated / classification
  • RNA, Untranslated / genetics*
  • Sequence Alignment
  • Sequence Analysis, RNA


  • RNA, Untranslated