Small RNAs Turn Over a New Leaf as Morphogens

Dana O Robinson; Adrienne H K Roeder

doi:10.1016/j.devcel.2017.10.025

Small RNAs Turn Over a New Leaf as Morphogens

Dev Cell. 2017 Nov 6;43(3):253-254. doi: 10.1016/j.devcel.2017.10.025.

Authors

Dana O Robinson¹, Adrienne H K Roeder²

Affiliations

¹ Weill Institute for Cell and Molecular Biology and School of Integrative Plant Science, Section of Plant Biology, Cornell University, Ithaca, NY, USA.
² Weill Institute for Cell and Molecular Biology and School of Integrative Plant Science, Section of Plant Biology, Cornell University, Ithaca, NY, USA. Electronic address: ahr75@cornell.edu.

PMID: 29112845
DOI: 10.1016/j.devcel.2017.10.025

Abstract

In this issue of Developmental Cell, Skopelitis et al. (2017) demonstrate that sharp boundaries of gene expression can be created by threshold-based readout of mobile small RNA gradients. Support for this hypothesis comes from manipulation of small RNAs involved in top-bottom leaf patterning and from a novel synthetic biology approach.

Publication types

Comment

MeSH terms

Animals
Body Patterning / genetics
Gene Expression Regulation, Developmental / genetics*
Humans
Models, Biological
Plant Leaves / genetics*
RNA / genetics*
Signal Transduction / genetics

Substances

RNA