Evidence for Converging DNA Methylation Pathways in Placenta and Cancer

Dev Cell. 2017 Nov 6;43(3):257-258. doi: 10.1016/j.devcel.2017.10.009.

Abstract

CpG island promoters are generally devoid of DNA methylation in somatic cells but are frequently methylated during tumorigenesis. Reporting recently in Nature, Smith et al. (2017) show that the signaling-induced methylome in early extraembryonic tissues resembles that of many cancers, suggesting that placental nuclear programming might be co-opted in tumorigenesis.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Carcinogenesis / genetics*
  • CpG Islands / genetics*
  • DNA Methylation / physiology*
  • Female
  • Humans
  • Neoplasms / genetics*
  • Placenta / metabolism*
  • Pregnancy
  • Promoter Regions, Genetic / genetics