Evidence for Converging DNA Methylation Pathways in Placenta and Cancer

Dev Cell. 2017 Nov 6;43(3):257-258. doi: 10.1016/j.devcel.2017.10.009.


CpG island promoters are generally devoid of DNA methylation in somatic cells but are frequently methylated during tumorigenesis. Reporting recently in Nature, Smith et al. (2017) show that the signaling-induced methylome in early extraembryonic tissues resembles that of many cancers, suggesting that placental nuclear programming might be co-opted in tumorigenesis.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Carcinogenesis / genetics*
  • CpG Islands / genetics*
  • DNA Methylation / physiology*
  • Female
  • Humans
  • Neoplasms / genetics*
  • Placenta / metabolism*
  • Pregnancy
  • Promoter Regions, Genetic / genetics