Vms1 Relieves a Mitochondrial Import Chokehold

Dev Cell. 2017 Nov 6;43(3):259-260. doi: 10.1016/j.devcel.2017.10.022.

Abstract

Ribosome stalling results in the production of truncated proteins that can cause proteotoxic stress if not efficiently degraded. A recent paper by Izawa et al. (2017) identifies Vms1 as a key player in the regulation of ribosome quality control specifically on mitochondria-localized ribosomes, ultimately preventing protein aggregate accumulation within mitochondria.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Carrier Proteins / metabolism*
  • Humans
  • Mitochondria / metabolism*
  • Mitochondrial Proteins / metabolism
  • Ribosomes / metabolism
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism*

Substances

  • Carrier Proteins
  • Mitochondrial Proteins
  • Saccharomyces cerevisiae Proteins
  • Vms1 protein, S cerevisiae