Dietary Zinc Acts as a Sleep Modulator

Int J Mol Sci. 2017 Nov 5;18(11):2334. doi: 10.3390/ijms18112334.


While zinc is known to be important for many biological processes in animals at a molecular and physiological level, new evidence indicates that it may also be involved in the regulation of sleep. Recent research has concluded that zinc serum concentration varies with the amount of sleep, while orally administered zinc increases the amount and the quality of sleep in mice and humans. In this review, we provide an exhaustive study of the literature connecting zinc and sleep, and try to evaluate which molecular mechanism is likely to be involved in this phenomenon. A better understanding should provide critical information not only about the way zinc is related to sleep but also about how sleep itself works and what its real function is.

Keywords: brain; nutrition; randomized controlled trial; sleep; zinc.

Publication types

  • Review

MeSH terms

  • Animals
  • Dietary Supplements
  • Humans
  • Sleep / drug effects*
  • Sleep Aids, Pharmaceutical / administration & dosage
  • Sleep Aids, Pharmaceutical / pharmacology
  • Zinc / administration & dosage
  • Zinc / metabolism*
  • Zinc / pharmacology


  • Sleep Aids, Pharmaceutical
  • Zinc