Endophilin A2: A Potential Link to Adiposity and Beyond

Mol Cells. 2017 Nov 30;40(11):855-863. doi: 10.14348/molcells.2017.0137. Epub 2017 Nov 6.


Adipose tissue plays a central role in regulating dynamic crosstalk between tissues and organs. A detailed description of molecules that are differentially expressed upon changes in adipose tissue mass is expected to increase our understanding of the molecular mechanisms that underlie obesity and related metabolic co-morbidities. Our previous studies suggest a possible link between endophilins (SH3Grb2 proteins) and changes in body weight. To explore this further, we sought to assess the distribution of endophilin A2 (EA2) in human adipose tissue and experimental animals. Human paired adipose tissue samples (subcutaneous and visceral) were collected from subjects undergoing elective abdominal surgery and abdominal liposuction. We observed elevated EA2 gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 gene expression negatively correlated with adiponectin and chemerin in visceral adipose tissue, and positively correlated with TNF-α in subcutaneous adipose tissue. EA2 gene expression was significantly downregulated during differentiation of preadipocytes in vitro. In conclusion, this study provides a description of EA2 distribution and emphasizes a need to study the roles of this protein during the progression of obesity.

Keywords: SH3GL1; adipose tissue; endophilin A2; obesity.

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / cytology
  • Adipocytes / metabolism
  • Adiponectin / metabolism
  • Animals
  • Cell Differentiation
  • Chemokines / metabolism
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Intra-Abdominal Fat / metabolism*
  • Intra-Abdominal Fat / surgery
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Lipectomy
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Models, Animal
  • Organ Specificity
  • Subcutaneous Fat, Abdominal / metabolism*
  • Subcutaneous Fat, Abdominal / surgery
  • Tumor Necrosis Factor-alpha / metabolism
  • Up-Regulation*


  • ADIPOQ protein, human
  • Adiponectin
  • Chemokines
  • Intercellular Signaling Peptides and Proteins
  • Intracellular Signaling Peptides and Proteins
  • RARRES2 protein, human
  • SH3GL1 protein, human
  • TNF protein, human
  • Tumor Necrosis Factor-alpha