The combined effect of vitamin D and parathyroid hormone concentrations on glucose homeostasis in older patients with prediabetes: A cross-sectional study

Diab Vasc Dis Res. 2018 Mar;15(2):150-153. doi: 10.1177/1479164117738443. Epub 2017 Nov 8.


Background: The combined effect of vitamin D and parathyroid hormone on glucose homeostasis has not been adequately investigated. The aim of this study was to examine the role of parathyroid hormone/vitamin D axis on glucose homeostasis in elderly persons with prediabetes.

Methods: Patients with prediabetes ( n = 144) and healthy age-matched controls ( n = 81) were included in this cross-sectional study. Study parameters included anthropometric characteristics, morning fasting glucose (fasting plasma glucose), insulin (fasting plasma insulin), parathyroid hormone, 25-hydroxyvitamin D, homeostasis model assessment of insulin resistance and homeostasis model assessment of β-cell function. Both groups were stratified into subgroups according to vitamin D status and tertiles of parathyroid hormone.

Results: Both groups were comparable in terms of body mass index, 25-hydroxyvitamin D and parathyroid hormone status. In the prediabetes group, fasting plasma glucose differed significantly across parathyroid hormone tertiles, increasing from the first to the third tertile ( p = 0.011). There were higher fasting plasma glucose values in participants with vitamin D deficiency/parathyroid hormone third tertile compared to all other groups ( p = 0.031, 0.027 and 0.039, respectively).

Conclusion: Parathyroid hormone status is associated with impaired glucose homeostasis; hypovitaminosis D combined with high parathyroid hormone concentrations are associated with glycaemic dysregulation in elderly patients with prediabetes.

Keywords: Vitamin D; glucose homeostasis; insulin resistance; insulin sensitivity; parathyroid hormone; prediabetes.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism*
  • Body Mass Index
  • Cross-Sectional Studies
  • Fasting
  • Female
  • Homeostasis / drug effects
  • Homeostasis / physiology
  • Humans
  • Insulin Resistance / physiology
  • Male
  • Middle Aged
  • Parathyroid Hormone / metabolism
  • Parathyroid Hormone / therapeutic use*
  • Prediabetic State / complications
  • Prediabetic State / diagnosis
  • Prediabetic State / drug therapy*
  • Vitamin D / blood
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / blood


  • Blood Glucose
  • Parathyroid Hormone
  • Vitamin D